5Y1Q

Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(3-chlorobenzyl)ureido)-N-hydroxy-4-methylpentanamide

5Y1Q の概要

• エントリーDOI: 10.2210/pdb5y1q/pdb
• 分子名称: M1 family aminopeptidase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: m1-class aminopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 106743.58

構造登録者

Marapaka, A.K.,Zhang, Y.,Addlagatta, A. (登録日: 2017-07-21, 公開日: 2018-08-01, 最終更新日: 2023-11-22)

• 主引用文献: Marapaka, A.K.,Sankoju, P.,Zhang, G.,Ding, Y.,Ma, C.,Pillalamarri, V.,Sudhakar, P.,Reddi, B.,Sijwali, P.S.,Zhang, Y.,Addlagatta, A.; Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization; Chin.Chem.Lett., 33:2550-2554, 2022; DOI: 10.1016/j.cclet.2021.09.102

実験手法

X-RAY DIFFRACTION (2.14 Å)