5Y0B

PIG GASTRIC H+,K+ - ATPASE IN COMPLEX with BYK99

5Y0B の概要

• エントリーDOI: 10.2210/pdb5y0b/pdb
• EMDBエントリー: 6799
• 分子名称: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta (2 entities in total)
• 機能のキーワード: ion pump, h+, k+-atpase, p-type atpase, membrane protein, hydrolase, e2, aluminium fluoride, atp-binding, hydrogen ion transport, ion transport, magnesium, membrane, metal-binding, nucleotide-binding, phosphoprotein, potassium, potassium transport, transmembrane, transport, disulfide bond, glycoprotein, signal-anchor
• 由来する生物種: Sus scrofa (Pig); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P19156; Cell membrane ; Single-pass type II membrane protein : P18434
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 147513.53

構造登録者

Abe, K.,Shimokawa, J.,Natio, M.,Munson, K.,Vagin, O.,Sachs, G.,Suzuki, H.,Tani, K.,Fujiyoshi, Y. (登録日: 2017-07-16, 公開日: 2017-08-09)

• 主引用文献: Abe, K.,Shimokawa, J.,Naito, M.,Munson, K.,Vagin, O.,Sachs, G.,Suzuki, H.,Tani, K.,Fujiyoshi, Y.; The cryo-EM structure of gastric H(+),K(+)-ATPase with bound BYK99, a high-affinity member of K(+)-competitive, imidazo[1,2-a]pyridine inhibitors; Sci Rep, 7:6632-6632, 2017; PubMed: 28747707; DOI: 10.1038/s41598-017-06698-8

実験手法

ELECTRON CRYSTALLOGRAPHY (6.7 Å)