5XZE

Mouse cGAS bound to the inhibitor RU332

Summary for 5XZE

• Entry DOI: 10.2210/pdb5xze/pdb
• Descriptor: Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), DNA (5'-D(P*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*TP*T)-3'), ... (6 entities in total)
• Functional Keywords: inhibitor, cgas, sting, immune system-inhibitor complex, immune system/inhibitor
• Biological source: Mus musculus (Mouse); More
• Cellular location: Cytoplasm, cytosol : Q8C6L5
• Total number of polymer chains: 3
• Total formula weight: 51816.74

Authors

Vincent, J.,Adura, C.,Gao, P.,Luz, A.,Lama, L.,Asano, Y.,Okamoto, R.,Imaeda, T.,Aida, J.,Rothamel, K.,Gogakos, T.,Steinberg, J.,Reasoner, S.,Aso, K.,Tuschl, T.,Patel, D.J.,Glickman, J.F.,Ascano, M. (deposition date: 2017-07-12, release date: 2017-10-11, Last modification date: 2024-03-13)

• Primary citation: Vincent, J.,Adura, C.,Gao, P.,Luz, A.,Lama, L.,Asano, Y.,Okamoto, R.,Imaeda, T.,Aida, J.,Rothamel, K.,Gogakos, T.,Steinberg, J.,Reasoner, S.,Aso, K.,Tuschl, T.,Patel, D.J.,Glickman, J.F.,Ascano, M.; Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.; Nat Commun, 8:750-750, 2017; PubMed: 28963528; DOI: 10.1038/s41467-017-00833-9

Experimental method

X-RAY DIFFRACTION (2.177 Å)