5XZ3

The X-ray structure of Apis mellifera PGRP-SA

5XZ3 の概要

• エントリーDOI: 10.2210/pdb5xz3/pdb
• 分子名称: Peptidoglycan-recognition protein, SULFATE ION (3 entities in total)
• 機能のキーワード: apis mellifera, pgrp-sa, immune system
• 由来する生物種: Apis mellifera (Honeybee)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 79077.53

構造登録者

Liu, Y.J.,Huang, J.X.,Zhao, X.M.,An, J.D. (登録日: 2017-07-11, 公開日: 2018-07-18, 最終更新日: 2024-10-16)

主引用文献

Liu, Y.,Zhao, X.,Naeem, M.,An, J.
Crystal structure of peptidoglycan recognition protein SA in Apis mellifera (Hymenoptera: Apidae).
Protein Sci., 27:893-897, 2018

PubMed Abstract: Peptidoglycan recognition protein SA (PGRP-SA) is a key pattern recognition receptor in the insect innate immune system. PGRP-SA can bind to bacterial PGN and activate the Toll pathway, which triggers the expression and release of antimicrobial peptides to prevent bacterial infection. Here, we report the first structure of Apis mellifera PGRP-SA from Hymenoptera at 1.86 Å resolution. The overall architecture of Am-PGRP-SA was similar to the Drosophila PGRP-SA; however, the residues involved in PGN binding groove were not conserved, and the binding pocket was narrower. This structure gives insight into PGN binding characteristics in honeybees.

PubMed: 29396863
DOI: 10.1002/pro.3383

実験手法

X-RAY DIFFRACTION (1.86 Å)