5XYY
The structure of p38 alpha in complex with a triazol inhibitor
Summary for 5XYY
Entry DOI | 10.2210/pdb5xyy/pdb |
Descriptor | Mitogen-activated protein kinase 14, 3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-4H-1,2,4-triazol-3-yl)phenol (3 entities in total) |
Functional Keywords | p38 map kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 43833.28 |
Authors | |
Primary citation | Wang, Y.,Sun, Y.,Cao, R.,Liu, D.,Xie, Y.,Li, L.,Qi, X.,Huang, N. In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery. J. Med. Chem., 60:8552-8564, 2017 Cited by PubMed: 28945083DOI: 10.1021/acs.jmedchem.7b01075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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