5XW6

Crystal structure of the chicken ATP-gated P2X7 receptor channel in the presence of competitive antagonist TNP-ATP at 3.1 Angstroms

Summary for 5XW6

Entry DOI	10.2210/pdb5xw6/pdb
Descriptor	P2X purinoceptor, 2-acetamido-2-deoxy-beta-D-glucopyranose, SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE (3 entities in total)
Functional Keywords	ion channel, ligand-gated ion channel, p2x receptor, p2x7 receptor, tnp-atp, membrane protein
Biological source	Gallus gallus (Chicken)
Total number of polymer chains	3
Total formula weight	114843.98
Authors	Kasuya, G.,Hattori, M.,Nureki, O. (deposition date: 2017-06-29, release date: 2017-10-25, Last modification date: 2023-11-22)
Primary citation	Kasuya, G.,Yamaura, T.,Ma, X.B.,Nakamura, R.,Takemoto, M.,Nagumo, H.,Tanaka, E.,Dohmae, N.,Nakane, T.,Yu, Y.,Ishitani, R.,Matsuzaki, O.,Hattori, M.,Nureki, O. Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel Nat Commun, 8:876-876, 2017 Cited by PubMed: 29026074 DOI: 10.1038/s41467-017-00887-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation