5XVF
Crystal Structure of PAK4 in complex with inhibitor CZH062
Summary for 5XVF
Entry DOI | 10.2210/pdb5xvf/pdb |
Descriptor | Serine/threonine-protein kinase PAK 4, 2-(4-azanylpiperidin-1-yl)-6-chloranyl-N-(1-methylimidazol-4-yl)quinazolin-4-amine (3 entities in total) |
Functional Keywords | atp binding pocket, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : O96013 |
Total number of polymer chains | 1 |
Total formula weight | 33040.80 |
Authors | |
Primary citation | Hao, C.,Zhao, F.,Song, H.,Guo, J.,Li, X.,Jiang, X.,Huan, R.,Song, S.,Zhang, Q.,Wang, R.,Wang, K.,Pang, Y.,Liu, T.,Lu, T.,Huang, W.,Wang, J.,Lin, B.,He, Z.,Li, H.,Li, F.,Zhao, D.,Cheng, M. Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J. Med. Chem., 61:265-285, 2018 Cited by PubMed: 29190083DOI: 10.1021/acs.jmedchem.7b01342 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.655 Å) |
Structure validation
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