5XV7

SRPK1 in complex with Alectinib

5XV7 の概要

• エントリーDOI: 10.2210/pdb5xv7/pdb
• 分子名称: serine-arginine (SR) protein kinase 1, 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, ... (4 entities in total)
• 機能のキーワード: srpk1, alectinib, srpkin-1, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43157.73

構造登録者

Zeng, C.,Ngo, J.C.K. (登録日: 2017-06-26, 公開日: 2018-03-14, 最終更新日: 2023-11-22)

• 主引用文献: Hatcher, J.M.,Wu, G.,Zeng, C.,Zhu, J.,Meng, F.,Patel, S.,Wang, W.,Ficarro, S.B.,Leggett, A.L.,Powell, C.E.,Marto, J.A.,Zhang, K.,Ki Ngo, J.C.,Fu, X.D.,Zhang, T.,Gray, N.S.; SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform; Cell Chem Biol, 25:460-470.e6, 2018; PubMed: 29478907; DOI: 10.1016/j.chembiol.2018.01.013

実験手法

X-RAY DIFFRACTION (2.32 Å)