5XUQ

Crystal structure of VDR-LBD complexed with an antagonist, 2-methylidene-19,26,27-trinor-22-(S)-butyl-1-hydroxy-25-oxo-25-(1H-pyrrol-2-yl)- vitamin D3

Summary for 5XUQ

• Entry DOI: 10.2210/pdb5xuq/pdb
• Descriptor: Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (4~{S})-4-[(1~{R})-1-[(1~{R},3~{a}~{S},4~{E},7~{a}~{R})-7~{a}-methyl-4-[2-[(3~{R},5~{R})-4-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-1-yl]ethyl]-1-(1~{H}-pyrrol-2-yl)octan-1-one, ... (4 entities in total)
• Functional Keywords: vitamin d receptor antagonist helix 10/11, transcription
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 2
• Total formula weight: 32673.68

Authors

Kato, A.,Itoh, T.,Yamamoto, K. (deposition date: 2017-06-24, release date: 2018-06-27, Last modification date: 2024-03-27)

• Primary citation: Kato, A.,Tabei, M.,Itoh, T.,Yamamoto, K.; Discovery of Potent Vitamin D Receptor Antagonist; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)