5XT6

A sulfur-transferring catalytic intermediate of SufS-SufU complex from Bacillus subtilis

Summary for 5XT6

Entry DOI	10.2210/pdb5xt6/pdb
Descriptor	Zinc-dependent sulfurtransferase SufU, Cysteine desulfurase SufS, ZINC ION, ... (6 entities in total)
Functional Keywords	iron-sulfur cluster biosynthesis, suf machinery, cysteine desulfurase, sulfur mobilization, metalloprotein, biosynthetic protein
Biological source	Bacillus subtilis (strain 168) More
Total number of polymer chains	4
Total formula weight	128553.92
Authors	Fujishiro, T.,Kunichika, K.,Takahashi, Y. (deposition date: 2017-06-17, release date: 2017-12-20, Last modification date: 2024-10-23)
Primary citation	Fujishiro, T.,Terahata, T.,Kunichika, K.,Yokoyama, N.,Maruyama, C.,Asai, K.,Takahashi, Y. Zinc-Ligand Swapping Mediated Complex Formation and Sulfur Transfer between SufS and SufU for Iron-Sulfur Cluster Biogenesis in Bacillus subtilis J. Am. Chem. Soc., 139:18464-18467, 2017 Cited by PubMed Abstract: SufU is a zinc-containing protein involved in mobilization of sulfur from SufS for iron-sulfur cluster biogenesis of Bacillus subtilis. Structural basis for the sulfur transfer in SufS-SufU complex was revealed. A zinc-ligand exchange reaction upon SufS-SufU complexation provides a free thiol from Cys41 of SufU as a sulfur acceptor. PubMed: 29235855 DOI: 10.1021/jacs.7b11307 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation