5XT6

A sulfur-transferring catalytic intermediate of SufS-SufU complex from Bacillus subtilis

5XT6 の概要

• エントリーDOI: 10.2210/pdb5xt6/pdb
• 分子名称: Zinc-dependent sulfurtransferase SufU, Cysteine desulfurase SufS, ZINC ION, ... (6 entities in total)
• 機能のキーワード: iron-sulfur cluster biosynthesis, suf machinery, cysteine desulfurase, sulfur mobilization, metalloprotein, biosynthetic protein
• 由来する生物種: Bacillus subtilis (strain 168); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128553.92

構造登録者

Fujishiro, T.,Kunichika, K.,Takahashi, Y. (登録日: 2017-06-17, 公開日: 2017-12-20, 最終更新日: 2024-10-23)

主引用文献

Fujishiro, T.,Terahata, T.,Kunichika, K.,Yokoyama, N.,Maruyama, C.,Asai, K.,Takahashi, Y.
Zinc-Ligand Swapping Mediated Complex Formation and Sulfur Transfer between SufS and SufU for Iron-Sulfur Cluster Biogenesis in Bacillus subtilis
J. Am. Chem. Soc., 139:18464-18467, 2017

PubMed Abstract: SufU is a zinc-containing protein involved in mobilization of sulfur from SufS for iron-sulfur cluster biogenesis of Bacillus subtilis. Structural basis for the sulfur transfer in SufS-SufU complex was revealed. A zinc-ligand exchange reaction upon SufS-SufU complexation provides a free thiol from Cys41 of SufU as a sulfur acceptor.

PubMed: 29235855
DOI: 10.1021/jacs.7b11307

実験手法

X-RAY DIFFRACTION (3.5 Å)