5XPM

Crystal structure of VDR-LBD complexed with 22S-Butyl-25RS-(hydroxyphenyl)-25-methoxy-2-methylidene-19,26,27-trinor-1-hydroxyvitamin D3

5XPM の概要

• エントリーDOI: 10.2210/pdb5xpm/pdb
• 分子名称: Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1~{R},3~{R})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-1-[(2~{R},3~{S})-3-[(3~{S})-3-(4-hydroxyphenyl)-3-methoxy-propyl]heptan-2-yl]-7~{a}-methyl-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol, ... (4 entities in total)
• 機能のキーワード: transcription, vitamin d3, vdr, vdre, rxr, co-factors
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32716.75

構造登録者

Kato, A.,Itoh, T.,Yamamoto, K. (登録日: 2017-06-03, 公開日: 2018-06-06, 最終更新日: 2024-03-27)

• 主引用文献: Kato, A.,Yamao, M.,Hashihara, Y.,Ishida, H.,Itoh, T.,Yamamoto, K.; Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action; J. Med. Chem., 60:8394-8406, 2017; PubMed: 28954197; DOI: 10.1021/acs.jmedchem.7b00819

実験手法

X-RAY DIFFRACTION (2.2 Å)