5XP8
Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 4A5 on the guide strand
Summary for 5XP8
Entry DOI | 10.2210/pdb5xp8/pdb |
Descriptor | TtAgo, DNA (5'-D(P*TP*GP*AP*GP*AP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), DNA (5'-D(*CP*AP*AP*CP*C*AP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ... (5 entities in total) |
Functional Keywords | argonaute, mirna, bulge, mismatch, dna binding protein |
Biological source | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) More |
Total number of polymer chains | 4 |
Total formula weight | 90313.50 |
Authors | Sheng, G.,Gogakos, T.,Wang, J.,Zhao, H.,Serganov, A.,Juranek, S.,Tuschl, T.,Patel, J.D.,Wang, Y. (deposition date: 2017-06-01, release date: 2018-04-18, Last modification date: 2023-11-22) |
Primary citation | Sheng, G.,Gogakos, T.,Wang, J.,Zhao, H.,Serganov, A.,Juranek, S.,Tuschl, T.,Patel, D.J.,Wang, Y. Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. Nucleic Acids Res., 45:9149-9163, 2017 Cited by PubMed: 28911094DOI: 10.1093/nar/gkx547 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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