5XNV

Crystal structure of YEATS2 YEATS bound to H3K27ac peptide

Summary for 5XNV

Entry DOI	10.2210/pdb5xnv/pdb
Descriptor	YEATS domain-containing protein 2, ALA-ALA-ARG-ALY-SER-ALA-PRO-ALA, AMMONIUM ION, ... (5 entities in total)
Functional Keywords	epigenetics, histone reader, histone acetylation, protein complex, protein binding-peptide complex, protein binding/peptide
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : Q9ULM3
Total number of polymer chains	2
Total formula weight	16721.60
Authors	Li, H.T.,Guan, H.P.,Zhao, D. (deposition date: 2017-05-24, release date: 2017-11-01, Last modification date: 2023-11-22)
Primary citation	Mi, W.,Guan, H.,Lyu, J.,Zhao, D.,Xi, Y.,Jiang, S.,Andrews, F.H.,Wang, X.,Gagea, M.,Wen, H.,Tora, L.,Dent, S.Y.R.,Kutateladze, T.G.,Li, W.,Li, H.,Shi, X. YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nat Commun, 8:1088-1088, 2017 Cited by PubMed: 29057918 DOI: 10.1038/s41467-017-01173-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.696 Å)

Structure validation