5XMQ

Plasmodium vivax SHMT(C346A) bound with PLP-glycine and MF011

5XMQ の概要

• エントリーDOI: 10.2210/pdb5xmq/pdb
• 分子名称: Serine hydroxymethyltransferase, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], 4-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-(trifluoromethyl)phenyl]-~{N}-methyl-~{N}-(phenylmethyl)benzenesulfonamide, ... (5 entities in total)
• 機能のキーワード: alpha and beta protein, methyltransferase activity, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Plasmodium vivax
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 150505.85

構造登録者

Chitnumsub, P.,Jaruwat, A.,Leartsakulpanich, U.,Schwertz, G.,Diederich, F. (登録日: 2017-05-16, 公開日: 2017-11-29, 最終更新日: 2023-11-22)

• 主引用文献: Schwertz, G.,Frei, M.S.,Witschel, M.C.,Rottmann, M.,Leartsakulpanich, U.,Chitnumsub, P.,Jaruwat, A.,Ittarat, W.,Schafer, A.,Aponte, R.A.,Trapp, N.,Mark, K.,Chaiyen, P.,Diederich, F.; Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs; Chemistry, 23:14345-14357, 2017; PubMed: 28967982; DOI: 10.1002/chem.201703244

実験手法

X-RAY DIFFRACTION (2.2 Å)