5XMH

Crystal structure of an IgM rheumatoid factor YES8c in complex with IgG1 Fc

Summary for 5XMH

• Entry DOI: 10.2210/pdb5xmh/pdb
• Descriptor: Immunoglobulin gamma-1 heavy chain, YES8c light chain, YES8c heavy chain, ... (6 entities in total)
• Functional Keywords: immunoglobulin, complex, rheumatoid factor, autoantibody, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted : P0DOX5
• Total number of polymer chains: 6
• Total formula weight: 144696.60

Authors

Shiroishi, M.,Shimokawa, K.,Lee, J.M.,Kusakabe, M.,Ueda, T. (deposition date: 2017-05-15, release date: 2018-03-21, Last modification date: 2020-07-29)

• Primary citation: Shiroishi, M.,Ito, Y.,Shimokawa, K.,Lee, J.M.,Kusakabe, T.,Ueda, T.; Structure-function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity.; J. Biol. Chem., 293:7008-7016, 2018; PubMed: 29523691; DOI: 10.1074/jbc.M117.814475

Experimental method

X-RAY DIFFRACTION (2.8 Å)