5XLZ

The crystal structure of tubulin complexed with a benzylidene derivative of 9(10H)-anthracenone

Summary for 5XLZ

• Entry DOI: 10.2210/pdb5xlz/pdb
• Descriptor: Tubulin alpha-1B chain, 10-[(4-methoxy-3-oxidanyl-phenyl)methylidene]anthracen-9-one, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: inhibitor, tubulin, cell cycle
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265047.50

Authors

Yu, Y.,Chen, Q. (deposition date: 2017-05-12, release date: 2017-11-22, Last modification date: 2024-03-27)

• Primary citation: Cheng, J.,Wu, Y.,Wang, Y.,Wang, C.,Wang, Y.,Wu, C.,Zeng, S.,Yu, Y.,Chen, Q.; Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design.; Biochem. Biophys. Res. Commun., 495:185-188, 2018; PubMed: 29102632; DOI: 10.1016/j.bbrc.2017.10.104

Experimental method

X-RAY DIFFRACTION (2.298 Å)