5XLZ
The crystal structure of tubulin complexed with a benzylidene derivative of 9(10H)-anthracenone
Summary for 5XLZ
Entry DOI | 10.2210/pdb5xlz/pdb |
Descriptor | Tubulin alpha-1B chain, 10-[(4-methoxy-3-oxidanyl-phenyl)methylidene]anthracen-9-one, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | inhibitor, tubulin, cell cycle |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265047.50 |
Authors | |
Primary citation | Cheng, J.,Wu, Y.,Wang, Y.,Wang, C.,Wang, Y.,Wu, C.,Zeng, S.,Yu, Y.,Chen, Q. Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design. Biochem. Biophys. Res. Commun., 495:185-188, 2018 Cited by PubMed: 29102632DOI: 10.1016/j.bbrc.2017.10.104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.298 Å) |
Structure validation
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