5XLZ

The crystal structure of tubulin complexed with a benzylidene derivative of 9(10H)-anthracenone

5XLZ の概要

分子名称Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (12 entities in total)
機能のキーワードinhibitor, tubulin, cell cycle
由来する生物種Rattus norvegicus (Rat)
詳細
細胞内の位置Cytoplasm, cytoskeleton P81947 Q6B856
Golgi apparatus  P63043
ポリマー鎖数6
分子量合計265047.5
構造登録者
Yu, Y.,Chen, Q. (登録日: 2017-05-12, 公開日: 2017-11-22, 最終更新日: 2018-01-03)
主引用文献
Cheng, J.,Wu, Y.,Wang, Y.,Wang, C.,Wang, Y.,Wu, C.,Zeng, S.,Yu, Y.,Chen, Q.
Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design.
Biochem. Biophys. Res. Commun., 495:185-188, 2018
PubMed: 29102632 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bbrc.2017.10.104
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.298 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.248101.2%12.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード