5XLZ

The crystal structure of tubulin complexed with a benzylidene derivative of 9(10H)-anthracenone

5XLZ の概要

• エントリーDOI: 10.2210/pdb5xlz/pdb
• 分子名称: Tubulin alpha-1B chain, 10-[(4-methoxy-3-oxidanyl-phenyl)methylidene]anthracen-9-one, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: inhibitor, tubulin, cell cycle
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265047.50

構造登録者

Yu, Y.,Chen, Q. (登録日: 2017-05-12, 公開日: 2017-11-22, 最終更新日: 2024-03-27)

• 主引用文献: Cheng, J.,Wu, Y.,Wang, Y.,Wang, C.,Wang, Y.,Wu, C.,Zeng, S.,Yu, Y.,Chen, Q.; Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design.; Biochem. Biophys. Res. Commun., 495:185-188, 2018; PubMed: 29102632; DOI: 10.1016/j.bbrc.2017.10.104

実験手法

X-RAY DIFFRACTION (2.298 Å)