5XLT

The crystal structure of tubulin in complex with 4'-demethylepipodophyllotoxin

Summary for 5XLT

• Entry DOI: 10.2210/pdb5xlt/pdb
• Descriptor: Tubulin alpha-1B chain, (5S,5aR,8aR,9R)-9-(3,5-dimethoxy-4-oxidanyl-phenyl)-5-oxidanyl-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: tubulin, inhibitor, cell cycle
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265111.56

Authors

Yu, Y.,Chen, Q. (deposition date: 2017-05-11, release date: 2017-09-27, Last modification date: 2024-03-27)

• Primary citation: Niu, L.,Wang, Y.,Wang, C.,Wang, Y.,Jiang, X.,Ma, L.,Wu, C.,Yu, Y.,Chen, Q.; Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design; Biochem. Biophys. Res. Commun., 493:718-722, 2017; PubMed: 28864414; DOI: 10.1016/j.bbrc.2017.08.125

Experimental method

X-RAY DIFFRACTION (2.813 Å)