5XLT

The crystal structure of tubulin in complex with 4'-demethylepipodophyllotoxin

5XLT の概要

• エントリーDOI: 10.2210/pdb5xlt/pdb
• 分子名称: Tubulin alpha-1B chain, (5S,5aR,8aR,9R)-9-(3,5-dimethoxy-4-oxidanyl-phenyl)-5-oxidanyl-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: tubulin, inhibitor, cell cycle
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265111.56

構造登録者

Yu, Y.,Chen, Q. (登録日: 2017-05-11, 公開日: 2017-09-27, 最終更新日: 2024-03-27)

• 主引用文献: Niu, L.,Wang, Y.,Wang, C.,Wang, Y.,Jiang, X.,Ma, L.,Wu, C.,Yu, Y.,Chen, Q.; Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design; Biochem. Biophys. Res. Commun., 493:718-722, 2017; PubMed: 28864414; DOI: 10.1016/j.bbrc.2017.08.125

実験手法

X-RAY DIFFRACTION (2.813 Å)