5XKF

Crystal structure of T2R-TTL-MPC6827 complex

Summary for 5XKF

• Entry DOI: 10.2210/pdb5xkf/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-(4-methoxyphenyl)-N,2-dimethyl-quinazolin-4-amine, ... (12 entities in total)
• Functional Keywords: colchicine binding domain, tubulin inhibitor, tublin, mpc-6827, structural protein
• Biological source: Sus scrofa (Pig); More
• Cellular location: Cytoplasm, cytoskeleton: Q2XVP4 A0A287AGU7; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 264667.44

Authors

Wang, Y.,Yang, J.,Wang, T.,Chen, L. (deposition date: 2017-05-07, release date: 2018-04-18, Last modification date: 2024-03-27)

• Primary citation: Yan, W.,Yang, J.; Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)