5XKE

Crystal structure of T2R-TTL-Demecolcine complex

Summary for 5XKE

• Entry DOI: 10.2210/pdb5xke/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one, ... (12 entities in total)
• Functional Keywords: colchicine binding domain, tubulin inhibitor, tubulin, demecolcine, structural protein
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 6
• Total formula weight: 264851.62

Authors

Wang, Y.,Yang, J.,Wang, T.,Chen, L. (deposition date: 2017-05-07, release date: 2018-07-04, Last modification date: 2024-03-27)

• Primary citation: Yan, W.,Yang, J.; Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)