5XJF

Crystal structure of fucosylated IgG Fc Y296W mutant complexed with bis-glycosylated soluble form of Fc gamma receptor IIIa

5XJF の概要

• エントリーDOI: 10.2210/pdb5xjf/pdb
• 関連するPDBエントリー: 5XJE
• 分子名称: Immunoglobulin gamma-1 heavy chain, Low affinity immunoglobulin gamma Fc region receptor III-A, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: immune system, complex, fc fragment, igg, receptor, cd16, gamma
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 75341.47

構造登録者

Sakae, Y.,Satoh, T.,Yagi, H.,Yanaka, S.,Yamaguchi, T.,Isoda, Y.,Iida, S.,Okamoto, Y.,Kato, K. (登録日: 2017-05-01, 公開日: 2017-11-01, 最終更新日: 2023-11-22)

• 主引用文献: Sakae, Y.,Satoh, T.,Yagi, H.,Yanaka, S.,Yamaguchi, T.,Isoda, Y.,Iida, S.,Okamoto, Y.,Kato, K.; Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fc gamma receptor IIIa.; Sci Rep, 7:13780-13780, 2017; PubMed: 29062024; DOI: 10.1038/s41598-017-13845-8

実験手法

X-RAY DIFFRACTION (2.5 Å)