5XJE

Crystal structure of fucosylated IgG1 Fc complexed with bis-glycosylated soluble form of Fc gamma receptor IIIa

Summary for 5XJE

• Entry DOI: 10.2210/pdb5xje/pdb
• Related: 5XJF
• Descriptor: Immunoglobulin gamma-1 heavy chain, Low affinity immunoglobulin gamma Fc region receptor III-A, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: immune system, complex, fc fragment, igg, receptor, cd16, gamma
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 75076.20

Authors

Sakae, Y.,Satoh, T.,Yagi, H.,Yanaka, S.,Yamaguchi, T.,Isoda, Y.,Iida, S.,Okamoto, Y.,Kato, K. (deposition date: 2017-05-01, release date: 2017-11-01, Last modification date: 2023-11-22)

• Primary citation: Sakae, Y.,Satoh, T.,Yagi, H.,Yanaka, S.,Yamaguchi, T.,Isoda, Y.,Iida, S.,Okamoto, Y.,Kato, K.; Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fc gamma receptor IIIa.; Sci Rep, 7:13780-13780, 2017; PubMed: 29062024; DOI: 10.1038/s41598-017-13845-8

Experimental method

X-RAY DIFFRACTION (2.4 Å)