5XGH
Crystal structure of PI3K complex with an inhibitor
Summary for 5XGH
Entry DOI | 10.2210/pdb5xgh/pdb |
Related | 5XGI 5XGJ |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 3-[(4-fluorophenyl)methylamino]-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol, ... (6 entities in total) |
Functional Keywords | pi3k, inhibitor, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 156203.76 |
Authors | |
Primary citation | Yang, X.,Zhang, X.,Huang, M.,Song, K.,Li, X.,Huang, M.,Meng, L.,Zhang, J. New Insights into PI3K Inhibitor Design using X-ray Structures of PI3K alpha Complexed with a Potent Lead Compound. Sci Rep, 7:14572-14572, 2017 Cited by PubMed: 29109464DOI: 10.1038/s41598-017-15260-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.97 Å) |
Structure validation
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