5XF5

Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (R,S-configuration)

Summary for 5XF5

• Entry DOI: 10.2210/pdb5xf5/pdb
• Related: 5XF3 5XF4 5XF6
• Descriptor: Histone H3.1, SULFATE ION, Histone H4, ... (10 entities in total)
• Functional Keywords: nucleosome, histone adduct, ruthenium compound, binuclear metal-based agent, structural protein-dna complex, structural protein/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: P68431 P62805 P04908 P06899
• Total number of polymer chains: 10
• Total formula weight: 200674.40

Authors

Ma, Z.,Adhireksan, Z.,Murray, B.S.,Dyson, P.J.,Davey, C.A. (deposition date: 2017-04-07, release date: 2017-10-11, Last modification date: 2023-11-22)

• Primary citation: Davey, G.E.,Adhireksan, Z.,Ma, Z.,Riedel, T.,Sharma, D.,Padavattan, S.,Rhodes, D.,Ludwig, A.,Sandin, S.,Murray, B.S.,Dyson, P.J.,Davey, C.A.; Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation; Nat Commun, 8:1575-1575, 2017; PubMed: 29146919; DOI: 10.1038/s41467-017-01680-4

Experimental method

X-RAY DIFFRACTION (2.82 Å)