5XEW

Crystal structure of the [Ni2+-(chromomycin A3)2]-CCG repeats complex

「5ERZ」から置き換えられました

5XEW の概要

• エントリーDOI: 10.2210/pdb5xew/pdb
• 関連するPDBエントリー: 5ERZ 5ES0
• 分子名称: DNA (5'-D(*TP*TP*CP*CP*GP*CP*CP*GP*CP*CP*GP*AP*A)-3'), 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, ... (6 entities in total)
• 機能のキーワード: trinucleotide repeats, neurological disease, induced fit recognition, metal binding ligand, consecutive bases flip-out, dna deformation, molecular diagnostics, dna-antibiotic complex, dna/antibiotic
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 10343.74

構造登録者

Tseng, W.H.,Wu, P.C.,Hou, M.H. (登録日: 2017-04-06, 公開日: 2017-06-21, 最終更新日: 2024-03-27)

• 主引用文献: Tseng, W.H.,Chang, C.K.,Wu, P.C.,Hu, N.J.,Lee, G.H.,Tzeng, C.C.,Neidle, S.,Hou, M.H.; Induced-Fit Recognition of CCG Trinucleotide Repeats by a Nickel-Chromomycin Complex Resulting in Large-Scale DNA Deformation; Angew. Chem. Int. Ed. Engl., 56:8761-8765, 2017; PubMed: 28544401; DOI: 10.1002/anie.201703989

実験手法

X-RAY DIFFRACTION (1.751 Å)