5X9O
Crystal structure of the BCL6 BTB domain in complex with Compound 1a
Summary for 5X9O
Entry DOI | 10.2210/pdb5x9o/pdb |
Related | 5X9P |
Descriptor | B-cell lymphoma 6 protein, 5-[(2-chloranyl-4-nitro-phenyl)amino]-1,3-dihydrobenzimidazol-2-one, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | transcription repressor, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P41182 |
Total number of polymer chains | 1 |
Total formula weight | 16693.59 |
Authors | Sogabe, S.,Ida, K.,Lane, W.,Snell, G. (deposition date: 2017-03-08, release date: 2017-08-16, Last modification date: 2023-11-22) |
Primary citation | Yasui, T.,Yamamoto, T.,Sakai, N.,Asano, K.,Takai, T.,Yoshitomi, Y.,Davis, M.,Takagi, T.,Sakamoto, K.,Sogabe, S.,Kamada, Y.,Lane, W.,Snell, G.,Iwata, M.,Goto, M.,Inooka, H.,Sakamoto, J.I.,Nakada, Y.,Imaeda, Y. Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25:4876-4886, 2017 Cited by PubMed: 28760529DOI: 10.1016/j.bmc.2017.07.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
Download full validation report