5X93

Human endothelin receptor type-B in complex with antagonist K-8794

Summary for 5X93

• Entry DOI: 10.2210/pdb5x93/pdb
• Descriptor: Endothelin B receptor,Endolysin,Endothelin B receptor, 3-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]oxy-N-(2,6-dimethylphenyl)propanamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
• Functional Keywords: alpha helical, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Multi-pass membrane protein: P24530
• Total number of polymer chains: 1
• Total formula weight: 57555.78

Authors

Shihoya, W.,Nishizawa, T.,Yamashita, K.,Hirata, K.,Okuta, A.,Tani, K.,Fujiyoshi, Y.,Doi, T.,Nureki, O. (deposition date: 2017-03-05, release date: 2017-08-16, Last modification date: 2017-11-15)

• Primary citation: Shihoya, W.,Nishizawa, T.,Yamashita, K.,Inoue, A.,Hirata, K.,Kadji, F.M.N.,Okuta, A.,Tani, K.,Aoki, J.,Fujiyoshi, Y.,Doi, T.,Nureki, O.; X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog; Nat. Struct. Mol. Biol., 24:758-764, 2017; PubMed: 28805809; DOI: 10.1038/nsmb.3450

Experimental method

X-RAY DIFFRACTION (2.2 Å)