5X93
Human endothelin receptor type-B in complex with antagonist K-8794
Summary for 5X93
Entry DOI | 10.2210/pdb5x93/pdb |
Descriptor | Endothelin B receptor,Endolysin,Endothelin B receptor, 3-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]oxy-N-(2,6-dimethylphenyl)propanamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total) |
Functional Keywords | alpha helical, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein: P24530 |
Total number of polymer chains | 1 |
Total formula weight | 57555.78 |
Authors | Shihoya, W.,Nishizawa, T.,Yamashita, K.,Hirata, K.,Okuta, A.,Tani, K.,Fujiyoshi, Y.,Doi, T.,Nureki, O. (deposition date: 2017-03-05, release date: 2017-08-16, Last modification date: 2017-11-15) |
Primary citation | Shihoya, W.,Nishizawa, T.,Yamashita, K.,Inoue, A.,Hirata, K.,Kadji, F.M.N.,Okuta, A.,Tani, K.,Aoki, J.,Fujiyoshi, Y.,Doi, T.,Nureki, O. X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog Nat. Struct. Mol. Biol., 24:758-764, 2017 Cited by PubMed: 28805809DOI: 10.1038/nsmb.3450 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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