5X93

Human endothelin receptor type-B in complex with antagonist K-8794

5X93 の概要

• エントリーDOI: 10.2210/pdb5x93/pdb
• 分子名称: Endothelin B receptor,Endolysin,Endothelin B receptor, 3-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]oxy-N-(2,6-dimethylphenyl)propanamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
• 機能のキーワード: alpha helical, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein: P24530
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57555.78

構造登録者

Shihoya, W.,Nishizawa, T.,Yamashita, K.,Hirata, K.,Okuta, A.,Tani, K.,Fujiyoshi, Y.,Doi, T.,Nureki, O. (登録日: 2017-03-05, 公開日: 2017-08-16, 最終更新日: 2017-11-15)

• 主引用文献: Shihoya, W.,Nishizawa, T.,Yamashita, K.,Inoue, A.,Hirata, K.,Kadji, F.M.N.,Okuta, A.,Tani, K.,Aoki, J.,Fujiyoshi, Y.,Doi, T.,Nureki, O.; X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog; Nat. Struct. Mol. Biol., 24:758-764, 2017; PubMed: 28805809; DOI: 10.1038/nsmb.3450

実験手法

X-RAY DIFFRACTION (2.2 Å)