5X8F

Ternary complex structure of a double mutant I454RA456K of o-Succinylbenzoate CoA Synthetase (MenE) from Bacillus Subtilis bound with AMP and its product analogue OSB-NCoA at 1.76 angstrom

5X8F の概要

• エントリーDOI: 10.2210/pdb5x8f/pdb
• 関連するPDBエントリー: 5X8G
• 分子名称: 2-succinylbenzoate--CoA ligase, o-succinylbenzoyl-N-coenzyme A, ADENOSINE MONOPHOSPHATE, ... (8 entities in total)
• 機能のキーワード: adenylate-forming enzyme, acyl-coa synthetase, thioester conformation, coa, pantetheine tunnel, adp binding subsite, domain alternation, large conformational change, inter-domain linker, ligase
• 由来する生物種: Bacillus subtilis subsp. subtilis str. 168
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 223682.85

構造登録者

Chen, Y.,Guo, Z. (登録日: 2017-03-02, 公開日: 2017-06-07, 最終更新日: 2023-11-22)

• 主引用文献: Chen, Y.,Li, T.L.,Lin, X.,Li, X.,Li, X.D.,Guo, Z.; Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate-binding mode; J. Biol. Chem., 292:12296-12310, 2017; PubMed: 28559280; DOI: 10.1074/jbc.M117.790410

実験手法

X-RAY DIFFRACTION (1.763 Å)