5X7D
Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist
Summary for 5X7D
Entry DOI | 10.2210/pdb5x7d/pdb |
Descriptor | Chimera protein of Beta-2 adrenergic receptor and Lysozyme, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHOLESTEROL, ... (8 entities in total) |
Functional Keywords | gpcr, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi- pass membrane protein : P07550 |
Total number of polymer chains | 1 |
Total formula weight | 58946.53 |
Authors | Liu, X.,Ahn, S.,Kahsai, A.W.,Meng, K.-C.,Latorraca, N.R.,Pani, B.,Venkatakrishnan, A.J.,Masoudi, A.,Weis, W.I.,Dror, R.O.,Chen, X.,Lefkowitz, R.J.,Kobilka, B.K. (deposition date: 2017-02-25, release date: 2017-08-16, Last modification date: 2023-10-18) |
Primary citation | Liu, X.,Ahn, S.,Kahsai, A.W.,Meng, K.C.,Latorraca, N.R.,Pani, B.,Venkatakrishnan, A.J.,Masoudi, A.,Weis, W.I.,Dror, R.O.,Chen, X.,Lefkowitz, R.J.,Kobilka, B.K. Mechanism of intracellular allosteric beta 2AR antagonist revealed by X-ray crystal structure. Nature, 548:480-484, 2017 Cited by PubMed: 28813418DOI: 10.1038/nature23652 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.703 Å) |
Structure validation
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