5X7D

Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist

5X7D の概要

• エントリーDOI: 10.2210/pdb5x7d/pdb
• 分子名称: Chimera protein of Beta-2 adrenergic receptor and Lysozyme, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHOLESTEROL, ... (8 entities in total)
• 機能のキーワード: gpcr, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Multi- pass membrane protein : P07550
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58946.53

構造登録者

Liu, X.,Ahn, S.,Kahsai, A.W.,Meng, K.-C.,Latorraca, N.R.,Pani, B.,Venkatakrishnan, A.J.,Masoudi, A.,Weis, W.I.,Dror, R.O.,Chen, X.,Lefkowitz, R.J.,Kobilka, B.K. (登録日: 2017-02-25, 公開日: 2017-08-16, 最終更新日: 2023-10-18)

• 主引用文献: Liu, X.,Ahn, S.,Kahsai, A.W.,Meng, K.C.,Latorraca, N.R.,Pani, B.,Venkatakrishnan, A.J.,Masoudi, A.,Weis, W.I.,Dror, R.O.,Chen, X.,Lefkowitz, R.J.,Kobilka, B.K.; Mechanism of intracellular allosteric beta 2AR antagonist revealed by X-ray crystal structure.; Nature, 548:480-484, 2017; PubMed: 28813418; DOI: 10.1038/nature23652

実験手法

X-RAY DIFFRACTION (2.703 Å)