5X60
Crystal structure of LSD1-CoREST in complex with peptide 9
Summary for 5X60
Entry DOI | 10.2210/pdb5x60/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, PEPTIDE SRTMQTARKSTGGKAPRKQL, ... (6 entities in total) |
Functional Keywords | demethylase, amine oxidase, chromatin, histone, fad, corepressor, oxidoreductase-transcription complex, oxidoreductase/transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : O60341 Q9UKL0 |
Total number of polymer chains | 3 |
Total formula weight | 93454.39 |
Authors | Kikuchi, M.,Amano, Y.,Sato, S.,Yokoyama, S.,Umezawa, N.,Higuchi, T.,Umehara, T. (deposition date: 2017-02-20, release date: 2017-04-12, Last modification date: 2023-11-22) |
Primary citation | Amano, Y.,Kikuchi, M.,Sato, S.,Yokoyama, S.,Umehara, T.,Umezawa, N.,Higuchi, T. Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1. Bioorg. Med. Chem., 25:2617-2624, 2017 Cited by PubMed: 28336409DOI: 10.1016/j.bmc.2017.03.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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