5X5O

Crystal structure of ZAK in complex with compound D2829

5X5O の概要

• エントリーDOI: 10.2210/pdb5x5o/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase MLT, N-[2,4-bis(fluoranyl)-3-[2-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]-3-bromanyl-benzenesulfonamide (3 entities in total)
• 機能のキーワード: zak, kinase, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q9NYL2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35856.82

構造登録者

Dai, Y.B.,Zhao, P.,Yun, C.H. (登録日: 2017-02-17, 公開日: 2017-12-27, 最終更新日: 2024-03-27)

• 主引用文献: Chang, Y.,Lu, X.,Shibu, M.A.,Dai, Y.B.,Luo, J.,Zhang, Y.,Li, Y.,Zhao, P.,Zhang, Z.,Xu, Y.,Tu, Z.C.,Zhang, Q.W.,Yun, C.H.,Huang, C.Y.,Ding, K.; Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.; J. Med. Chem., 60:5927-5932, 2017; PubMed: 28586211; DOI: 10.1021/acs.jmedchem.7b00572

実験手法

X-RAY DIFFRACTION (1.868 Å)