5X54

Crystal structure of the Keap1 Kelch domain in complex with a tetrapeptide

Summary for 5X54

Entry DOI	10.2210/pdb5x54/pdb
Descriptor	Kelch-like ECH-associated protein 1, ACE-GLU-TRP-TRP-TRP, ACETATE ION, ... (4 entities in total)
Functional Keywords	transcription, complex, inhibitor, kelch domain, nrf2, oxidative stress, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm: Q14145
Total number of polymer chains	4
Total formula weight	65178.68
Authors	Sogabe, S.,Kadotani, A.,Lane, W.,Snell, G. (deposition date: 2017-02-14, release date: 2017-03-29, Last modification date: 2023-11-22)
Primary citation	Sogabe, S.,Sakamoto, K.,Kamada, Y.,Kadotani, A.,Fukuda, Y.,Sakamoto, J. Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization Biochem. Biophys. Res. Commun., 486:620-625, 2017 Cited by PubMed: 28315327 DOI: 10.1016/j.bbrc.2017.03.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation