5X54

Crystal structure of the Keap1 Kelch domain in complex with a tetrapeptide

5X54 の概要

• エントリーDOI: 10.2210/pdb5x54/pdb
• 分子名称: Kelch-like ECH-associated protein 1, ACE-GLU-TRP-TRP-TRP, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: transcription, complex, inhibitor, kelch domain, nrf2, oxidative stress, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm: Q14145
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65178.68

構造登録者

Sogabe, S.,Kadotani, A.,Lane, W.,Snell, G. (登録日: 2017-02-14, 公開日: 2017-03-29, 最終更新日: 2023-11-22)

• 主引用文献: Sogabe, S.,Sakamoto, K.,Kamada, Y.,Kadotani, A.,Fukuda, Y.,Sakamoto, J.; Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization; Biochem. Biophys. Res. Commun., 486:620-625, 2017; PubMed: 28315327; DOI: 10.1016/j.bbrc.2017.03.038

実験手法

X-RAY DIFFRACTION (2.3 Å)