5X4P
Crystal structure of the BCL6 BTB domain in complex with Compound 6
Summary for 5X4P
| Entry DOI | 10.2210/pdb5x4p/pdb |
| Related | 5X4M 5X4N 5X4O 5X4Q |
| Descriptor | B-cell lymphoma 6 protein, 5-[(5-chloranylpyrimidin-4-yl)amino]-1,3-dihydroindol-2-one (3 entities in total) |
| Functional Keywords | transcription repressor, transcription-inhibitor complex, transcription/inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus : P41182 |
| Total number of polymer chains | 1 |
| Total formula weight | 16548.41 |
| Authors | Sogabe, S.,Ida, K.,Lane, W.,Snell, G. (deposition date: 2017-02-13, release date: 2017-05-24, Last modification date: 2023-11-22) |
| Primary citation | Kamada, Y.,Sakai, N.,Sogabe, S.,Ida, K.,Oki, H.,Sakamoto, K.,Lane, W.,Snell, G.,Iida, M.,Imaeda, Y.,Sakamoto, J.,Matsui, J. Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach J. Med. Chem., 60:4358-4368, 2017 Cited by PubMed: 28471657DOI: 10.1021/acs.jmedchem.7b00313 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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