5X4N

Crystal structure of the BCL6 BTB domain in complex with Compound 4

Summary for 5X4N

• Entry DOI: 10.2210/pdb5x4n/pdb
• Related: 5X4M 5X4O 5X4P 5X4Q
• Descriptor: B-cell lymphoma 6 protein, 5-chloro-N4-phenylpyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transcription repressor, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P41182
• Total number of polymer chains: 1
• Total formula weight: 16570.46

Authors

Sogabe, S.,Ida, K.,Lane, W.,Snell, G. (deposition date: 2017-02-13, release date: 2017-05-24, Last modification date: 2023-11-22)

• Primary citation: Kamada, Y.,Sakai, N.,Sogabe, S.,Ida, K.,Oki, H.,Sakamoto, K.,Lane, W.,Snell, G.,Iida, M.,Imaeda, Y.,Sakamoto, J.,Matsui, J.; Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach; J. Med. Chem., 60:4358-4368, 2017; PubMed: 28471657; DOI: 10.1021/acs.jmedchem.7b00313

Experimental method

X-RAY DIFFRACTION (1.94 Å)