5X2K
Crystal structure of EGFR 696-1022 T790M in complex with WZ4003
Summary for 5X2K
Entry DOI | 10.2210/pdb5x2k/pdb |
Related | 5X26 5X27 5X28 5X2A 5X2C 5X2K |
Descriptor | Epidermal growth factor receptor, N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide (3 entities in total) |
Functional Keywords | egfr, t790m, wz4003, wz4002, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 37829.19 |
Authors | |
Primary citation | Zhu, S.J.,Zhao, P.,Yang, J.,Ma, R.,Yan, X.E.,Yang, S.Y.,Yang, J.W.,Yun, C.H. Structural insights into drug development strategy targeting EGFR T790M/C797S. Oncotarget, 9:13652-13665, 2018 Cited by PubMed: 29568384DOI: 10.18632/oncotarget.24113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.201 Å) |
Structure validation
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