5WTB

Complex Structure of Staphylococcus aureus SdrE with human complement factor H

Summary for 5WTB

• Entry DOI: 10.2210/pdb5wtb/pdb
• Related: 5WTA
• Descriptor: Serine-aspartate repeat-containing protein E, Peptide from Complement factor H (2 entities in total)
• Functional Keywords: staphylococcus aureus, sdr family, complement factor h, complement evasion, cell adhesion
• Biological source: Staphylococcus aureus (strain Mu50 / ATCC 700699); More
• Cellular location: Secreted, cell wall ; Peptidoglycan-anchor : Q932F7; Secreted: P08603
• Total number of polymer chains: 8
• Total formula weight: 160823.95

Authors

Wu, M.,Zhang, Y.,Hang, T.,Wang, C.,Yang, Y.,Zang, J.,Zhang, M.,Zhang, X. (deposition date: 2016-12-10, release date: 2017-07-19, Last modification date: 2023-11-08)

• Primary citation: Zhang, Y.,Wu, M.,Hang, T.,Wang, C.,Yang, Y.,Pan, W.,Zang, J.,Zhang, M.,Zhang, X.; Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion; Biochem. J., 474:1619-1631, 2017; PubMed: 28258151; DOI: 10.1042/BCJ20170085

Experimental method

X-RAY DIFFRACTION (3.3 Å)