5WT9

Complex structure of PD-1 and nivolumab-Fab

Summary for 5WT9

• Entry DOI: 10.2210/pdb5wt9/pdb
• Descriptor: Heavy Chain of Nivolumab, Light Chain of Nivolumab, Programmed cell death protein 1, ... (5 entities in total)
• Functional Keywords: pd-1, nivolumab, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 67537.26

Authors

Tan, S.,Zhang, H.,Chai, Y.,Song, H.,Tong, Z.,Wang, Q.,Qi, J.,Wong, G.,Zhu, X.,Liu, W.J.,Gao, S.,Wang, Z.,Shi, Y.,Yang, F.,Gao, G.F.,Yan, J. (deposition date: 2016-12-10, release date: 2017-02-15, Last modification date: 2023-11-08)

• Primary citation: Tan, S.,Zhang, H.,Chai, Y.,Song, H.,Tong, Z.,Wang, Q.,Qi, J.,Wong, G.,Zhu, X.,Liu, W.J.,Gao, S.,Wang, Z.,Shi, Y.,Yang, F.,Gao, G.F.,Yan, J.; An unexpected N-terminal loop in PD-1 dominates binding by nivolumab.; Nat Commun, 8:14369-14369, 2017; PubMed: 28165004; DOI: 10.1038/ncomms14369

Experimental method

X-RAY DIFFRACTION (2.401 Å)