5WS7

Crystal structure of human MTH1(G2K/C87A/C104S mutant) in complex with 2-oxo-dATP

5WS7 の概要

• エントリーDOI: 10.2210/pdb5ws7/pdb
• 分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: alpha-beta-alpha sandwich, hydrolase, dna damage, dna repair, dna replication
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform p18: Cytoplasm. Isoform p26: Cytoplasm: P36639
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37097.24

構造登録者

Nakamura, T.,Waz, S.,Hirata, K.,Nakabeppu, Y.,Yamagata, Y. (登録日: 2016-12-05, 公開日: 2017-01-04, 最終更新日: 2023-11-08)

• 主引用文献: Waz, S.,Nakamura, T.,Hirata, K.,Koga-Ogawa, Y.,Chirifu, M.,Arimori, T.,Tamada, T.,Ikemizu, S.,Nakabeppu, Y.,Yamagata, Y.; Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity; J. Biol. Chem., 292:2785-2794, 2017; PubMed: 28035004; DOI: 10.1074/jbc.M116.749713

実験手法

X-RAY DIFFRACTION (1 Å)