5WS3

Crystal structures of human orexin 2 receptor bound to the selective antagonist EMPA determined by serial femtosecond crystallography at SACLA

5WS3 の概要

• エントリーDOI: 10.2210/pdb5ws3/pdb
• 分子名称: Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ... (5 entities in total)
• 機能のキーワード: receptor, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 66265.81

構造登録者

Suno, R.,Kimura, K.,Nakane, T.,Yamashita, K.,Wang, J.,Fujiwara, T.,Yamanaka, Y.,Im, D.,Tsujimoto, H.,Sasanuma, M.,Horita, S.,Hirokawa, T.,Nango, E.,Tono, K.,Kameshima, T.,Hatsui, T.,Joti, Y.,Yabashi, M.,Shimamoto, K.,Yamamoto, M.,Rosenbaum, D.M.,Iwata, S.,Shimamura, T.,Kobayashi, T. (登録日: 2016-12-05, 公開日: 2017-12-13, 最終更新日: 2023-11-08)

• 主引用文献: Suno, R.,Kimura, K.T.,Nakane, T.,Yamashita, K.,Wang, J.,Fujiwara, T.,Yamanaka, Y.,Im, D.,Horita, S.,Tsujimoto, H.,Tawaramoto, M.S.,Hirokawa, T.,Nango, E.,Tono, K.,Kameshima, T.,Hatsui, T.,Joti, Y.,Yabashi, M.,Shimamoto, K.,Yamamoto, M.,Rosenbaum, D.M.,Iwata, S.,Shimamura, T.,Kobayashi, T.; Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.; Structure, 26:7-19.e5, 2018; PubMed: 29225076; DOI: 10.1016/j.str.2017.11.005

実験手法

X-RAY DIFFRACTION (2.3 Å)