5WQC
Crystal structure of human orexin 2 receptor bound to the selective antagonist EMPA determined by the synchrotron light source at SPring-8.
Summary for 5WQC
Entry DOI | 10.2210/pdb5wqc/pdb |
Descriptor | Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ... (5 entities in total) |
Functional Keywords | g protein-coupled receptor, orexin neurotransmitters, orexin 2 receptor, orexin-a, orexin-b, empa, n-linked glycosylation, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi- pass membrane protein : O43614 |
Total number of polymer chains | 1 |
Total formula weight | 66310.00 |
Authors | Suno, R.,Hirata, K.,Yamashita, K.,Tsujimoto, H.,Sasanuma, M.,Horita, S.,Yamamoto, M.,Rosenbaum, D.M.,Iwata, S.,Shimamura, T.,Kobayashi, T. (deposition date: 2016-11-25, release date: 2017-11-29, Last modification date: 2018-01-17) |
Primary citation | Suno, R.,Kimura, K.T.,Nakane, T.,Yamashita, K.,Wang, J.,Fujiwara, T.,Yamanaka, Y.,Im, D.,Horita, S.,Tsujimoto, H.,Tawaramoto, M.S.,Hirokawa, T.,Nango, E.,Tono, K.,Kameshima, T.,Hatsui, T.,Joti, Y.,Yabashi, M.,Shimamoto, K.,Yamamoto, M.,Rosenbaum, D.M.,Iwata, S.,Shimamura, T.,Kobayashi, T. Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA Structure, 26:7-19.e5, 2018 Cited by PubMed: 29225076DOI: 10.1016/j.str.2017.11.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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