5WQA

Crystal structure of PDE4D catalytic domain complexed with Selaginpulvilins K

5WQA の概要

• エントリーDOI: 10.2210/pdb5wqa/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-[2-(4-hydroxyphenyl)ethynyl]-9,9-bis(4-methoxyphenyl)-7-oxidanyl-fluorene-2-carbaldehyde, ZINC ION, ... (5 entities in total)
• 機能のキーワード: natural pde4 inhibtor, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Apical cell membrane : Q08499
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78270.06

構造登録者

Huang, Y.,Zhang, T.,Zheng, X.,Yin, S.,Luo, H.B. (登録日: 2016-11-24, 公開日: 2017-02-22, 最終更新日: 2023-11-08)

• 主引用文献: Huang, Y.,Liu, X.,Wu, D.,Tang, G.,Lai, Z.,Zheng, X.,Yin, S.,Luo, H.B.; The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata; Biochem. Pharmacol., 130:51-59, 2017; PubMed: 28159622; DOI: 10.1016/j.bcp.2017.01.016

実験手法

X-RAY DIFFRACTION (2.3 Å)