5WP2

1.44 Angstrom crystal structure of CYP121 from Mycobacterium tuberculosis in complex with substrate and CN

Summary for 5WP2

Entry DOI	10.2210/pdb5wp2/pdb
Descriptor	Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, ... (6 entities in total)
Functional Keywords	complex, p450, oxidoreductase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	44527.77
Authors	Fielding, A.,Dornevil, K.,Liu, A. (deposition date: 2017-08-03, release date: 2018-05-30, Last modification date: 2023-10-04)
Primary citation	Fielding, A.J.,Dornevil, K.,Ma, L.,Davis, I.,Liu, A. Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature. J. Am. Chem. Soc., 139:17484-17499, 2017 Cited by PubMed: 29090577 DOI: 10.1021/jacs.7b08911 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.439 Å)

Structure validation