5WP2

1.44 Angstrom crystal structure of CYP121 from Mycobacterium tuberculosis in complex with substrate and CN

5WP2 の概要

• エントリーDOI: 10.2210/pdb5wp2/pdb
• 分子名称: Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, ... (6 entities in total)
• 機能のキーワード: complex, p450, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44527.77

構造登録者

Fielding, A.,Dornevil, K.,Liu, A. (登録日: 2017-08-03, 公開日: 2018-05-30, 最終更新日: 2023-10-04)

• 主引用文献: Fielding, A.J.,Dornevil, K.,Ma, L.,Davis, I.,Liu, A.; Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature.; J. Am. Chem. Soc., 139:17484-17499, 2017; PubMed: 29090577; DOI: 10.1021/jacs.7b08911

実験手法

X-RAY DIFFRACTION (1.439 Å)